Medicine candidates of rare earths nano-lanthanum hydroxide in preclinical studie: a novel phosphate binders
نویسندگان
چکیده
منابع مشابه
Lanthanum: a safe phosphate binder.
Accumulation of inorganic phosphate due to renal functional impairment contributes to the increased cardiovascular mortality observed in dialysis patients. Phosphate plays a causative role in the development of vascular calcification in renal failure; treatment with calcium-based phosphate binders and vitamin D can further increase the Ca x PO(4) product and add to the risk of ectopic mineraliz...
متن کاملExtractive metallurgy of rare earths
Although most of the rare earth metals were discovered in Sweden, the industrialisation started in the Austrian Empire. This was due to the fact that the Swedish chemist Jons Fridrik Bahr (1815–1875) from Uppsala went to Heidelberg in Germany in 1855 to analyse some rare earth minerals by the spectroscope discovered recently by chemistry professor Robert Bunsen (1811– 1899) and his colleague ph...
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Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption of sodium and phosphate. It is being studied in patients with chronic kidney disease requiring dialysis, who are often administered phosphate binders such as sevelamer to help ...
متن کاملEffects of phosphate binders in moderate CKD.
Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and efficacy in this population are not well understood. Here, we aimed to determine the effects of phosphate binders on parameters of mineral metabolism and vascular calcification among patients with moderate to advanced CKD. We randomly assigned ...
متن کاملEarths: Rare in Time, Not Space?
We compare two recent astrobiological approaches to the solution of the problem of the “Great Silence” (or Fermi’s paradox): the “rare Earth” hypothesis of Ward and Brownlee, and the phase-transition scenario of Annis. We show that they have important similarities, as far as self-selection of intelligent observers is concerned. In order to better illuminate the differences, we consider the dura...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_po2-4-4